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Journal: Diagnostics
Article Title: Investigation of Long-Term CD4+ T Cell Receptor Repertoire Changes Following SARS-CoV-2 Infection in Patients with Different Severities of Disease
doi: 10.3390/diagnostics14202330
Figure Lengend Snippet: Exploratory analysis by PCA comparing COVID-19 patients (all severity groups; inclusive of all collected timepoints). ( a ) ANOVA test for each TCR vb family ( p < 0.05 is considered statistically significant [circled]). ( b ) PCA performed using the TCR vb families with p < 0.05. Clustering separation between the groups can be observed. ( c ) Key loadings (features) on PC1. ( d ) Key loadings on PC2. ( e ) Classification modelling using backpropagation artificial neural networks (ANNs); the model shows good separation for MA and IP critical, and lower performance is noted for IP severe followed by IP moderate (correct responses shaded in yellow).
Article Snippet: Multivariate analyses were performed by means of principal component analysis (PCA) and
Techniques:
Journal: Diagnostics
Article Title: Investigation of Long-Term CD4+ T Cell Receptor Repertoire Changes Following SARS-CoV-2 Infection in Patients with Different Severities of Disease
doi: 10.3390/diagnostics14202330
Figure Lengend Snippet: Exploratory analysis by PCA comparing COVID-19 IP severity groups (all timepoints). ( a ) ANOVA test for each TCR vb family ( p < 0.05 is considered statistically significant [circled]). ( b ) PCA performed using the TCR vb families with p < 0.05. Good clustering separation between the groups can be observed. ( c ) Key loadings (features) on PC1. ( d ) Classification modelling using backpropagation artificial neural networks (ANNs); good classification between IP severity groups can be obtained (correct responses shaded in yellow), thus, given the TCR VB family CD4+ percentage, the model can predict if the patient is moderate, severe, or critical. ( e ) ROC analysis curves; performance characteristics indicate outstanding discrimination for classification of moderate and critical disease IPs, and excellent discrimination for severe disease IPs, sensitivity (blue), specificity (red).
Article Snippet: Multivariate analyses were performed by means of principal component analysis (PCA) and
Techniques: